Abstract
The emergence of new SARS-CoV-2 lineages able to escape antibodies elicited by infection or vaccination based on the Spike protein of the Wuhan isolates has reduced the ability of Spike-specific antibodies to protect previously infected or vaccinated individuals from infection. Therefore, the role played by T cells in the containment of viral replication and spread after infection has taken a more central stage. In this brief review, we will discuss the role played by T cells in the protection from COVID-19, with a particular emphasis on the kinetics of the T cell response and its localization at the site of primary infection.
Keywords: adaptive immunity against SARS-CoV-2; tissue-resident T cells.
【저자키워드】 tissue-resident T cells., adaptive immunity against SARS-CoV-2, 【초록키워드】 COVID-19, vaccination, adaptive, Immunity, antibody, T cells, Infection, Spread, Protein, T cell, viral replication, Lineage, T cell response, Primary infection, vaccinated individual, Spike-specific antibody, new SARS-CoV-2, PROTECT, reduced, elicited, the Spike, Wuhan isolate, 【제목키워드】 SARS-CoV-2, Kinetics, Localization, right, Act,