Abstract
The emergence of the SARS-CoV-2 Omicron variant has raised concerns of escape from vaccine-induced immunity. A number of studies have demonstrated a reduction in antibody-mediated neutralization of the Omicron variant in vaccinated individuals. Preliminary observations have suggested that T cells are less likely to be affected by changes in Omicron. However, the complexity of human leukocyte antigen genetics and its impact upon immunodominant T cell epitope selection suggests that the maintenance of T cell immunity may not be universal. In this study, we describe the impact that changes in Omicron BA.1, BA.2 and BA.3 have on recognition by spike-specific T cells. These T cells constitute the immunodominant CD8 + T cell response in HLA-A*29:02 + COVID-19 convalescent and vaccinated individuals; however, they fail to recognize the Omicron-encoded sequence. These observations demonstrate that in addition to evasion of antibody-mediated immunity, changes in Omicron variants can also lead to evasion of recognition by immunodominant T cell responses.
【초록키워드】 COVID-19, Immunity, T cells, neutralization, variant, omicron, CD8, genetics, Antigen, T cell, T cell responses, convalescent, epitope, T cell response, Vaccine-induced immunity, leukocyte, observation, sequence, vaccinated individuals, immunodominant, affected, addition, raised, less, changes in, recognize, demonstrated, suggested, reduction in, the SARS-CoV-2, 【제목키워드】 SARS-CoV-2, variant, omicron, epitope, CD8+ T cell, Ablation, immunodominant,