Abstract
Since immune system and internal environment <i>in vivo</i> are large and complex, the interpretation of the observed immune effect from the perspective of a single immune cell or antibody seems a little feeble. Many studies have shown that specific antibodies against ” former” viruses have a reduced ability to neutralize “new” mutant strains. However, there is no comprehensive and clear view of whether there will be Antibody-dependent enhancement (ADE). We review the latest relevant studies, hoping to explain the ADE of SARS-CoV-2 infection sometimes observed in some patients.
Keywords: SARS-CoV-2; antibody-dependent enhancement (ADE); countermeasures; mechanism; multiple roles of macrophages; receptor-mediated.
【저자키워드】 SARS-CoV-2, antibody-dependent enhancement (ADE), countermeasures, mechanism, receptor-mediated., multiple roles of macrophages, 【초록키워드】 antibody, Antibody-dependent enhancement, SARS-COV-2 infection, immune system, immune, Interpretation, in vivo, ADE, patients, Immune cell, Mutant strains, Perspective, complex, neutralize, shown, virus, specific antibody, reduced, explain, feeble, internal environment, 【제목키워드】 Antibody-dependent enhancement, ADE,