Abstract
Our study ( NCT04800133 ) aimed to determine the safety and immunogenicity in patients with IEIs receiving a 3-dose primary series of mRNA vaccine BNT162b2 (age 12+) or inactivated whole-virion vaccine CoronaVac (age 3+) in Hong Kong, including Omicron BA.1 neutralization, in a nonrandomized manner. Intradermal vaccination was also studied. Thirty-nine patients were vaccinated, including 16 with homologous intramuscular 0.3ml BNT162b2 and 17 with homologous intramuscular 0.5ml CoronaVac. Two patients received 3 doses of intradermal 0.5ml CoronaVac, and 4 patients received 2 doses of intramuscular BNT162b2 and the third dose with intradermal BNT162b2. No safety concerns were identified. Inadequate S-RBD IgG and surrogate virus neutralization responses were found after 2 doses in patients with humoral immunodeficiencies and especially so against BA.1. Dose 3 of either vaccine increased S-RBD IgG response. T cell responses against SARS-CoV-2 antigens were detected in vaccinated IEI patients by intracellular cytokine staining on flow cytometry. Intradermal third dose vaccine led to high antibody response in 4 patients. The primary vaccination series of BNT162b2 and CoronaVac in adults and children with IEIs should include 3 doses for optimal immunogenicity.
Keywords: BNT162b2; COVID-19; CoronaVac; inborn errors of immunity; vaccine.
【저자키워드】 COVID-19, CoronaVac, vaccine., BNT162b2, inborn errors of immunity, 【초록키워드】 IgG, Vaccine, vaccination, mRNA vaccine, neutralization, children, Antibody Response, immunodeficiency, omicron, flow cytometry, S-RBD, response, Patient, Virus neutralization, age, SARS-CoV-2 antigen, Hong Kong, homologous, patients, T cell response, inactivated, intramuscular, Intradermal, dose, humoral, IgG response, intracellular cytokine staining, include, receiving, Two patient, determine, Inadequate, nonrandomized, of BNT162b2, 【제목키워드】 Safety, Immunity, children, dose, of BNT162b2,