Abstract
Evaluation of the safety and immunogenicity of new vaccine platforms is needed to increase public acceptance of coronavirus disease 2019 (COVID-19) vaccines. Here, we evaluated the association between reactogenicity and immunogenicity in healthy adults following vaccination by analyzing blood samples before and after sequential two-dose vaccinations of BNT162b2 and ChAdOx1 nCoV-19. Outcomes included anti-S IgG antibody and neutralizing antibody responses, adverse events, and proinflammatory cytokine responses. A total of 59 and 57 participants vaccinated with BNT162b2 and ChAdOx1 nCoV-19, respectively, were enrolled. Systemic adverse events were more common after the first ChAdOx1 nCoV-19 dose than after the second. An opposite trend was observed in BNT162b2 recipients. Although the first ChAdOx1 nCoV-19 dose significantly elevated the median proinflammatory cytokine levels, the second dose did not, and neither did either dose of BNT162b2. Grades of systemic adverse events in ChAdOx1 nCoV-19 recipients were significantly associated with IL-6 and IL-1β levels. Anti-S IgG and neutralizing antibody titers resulting from the second BNT162b2 dose were significantly associated with fever. In conclusion, systemic adverse events resulting from the first ChAdOx1 nCoV-19 dose may be associated with proinflammatory cytokine responses rather than humoral immune responses. Febrile reactions after second BNT162b2 dose were positively correlated with vaccine-induced immune responses rather than with inflammatory responses.
Keywords: COVID-19; cytokine; immunogenicity; reactogenicity; vaccine.
【저자키워드】 COVID-19, immunogenicity, reactogenicity, cytokine, vaccine., 【초록키워드】 coronavirus disease, IgG, Vaccine, vaccination, Inflammatory responses, Vaccines, antibody, IL-6, BNT162b2, adverse events, response, Fever, adverse event, vaccine platform, humoral immune responses, ChAdOx1 nCoV-19, Neutralizing antibody titer, anti-S IgG, association, IL-1β, dose, systemic, GRADE, Proinflammatory cytokine, reaction, recipients, second dose, blood sample, participant, neutralizing antibody responses, recipient, vaccine-induced immune response, opposite, responses, enrolled, resulting, significantly, healthy, evaluated, elevated, of BNT162b2, positively correlated, systemic adverse event, the median, 【제목키워드】 COVID-19 vaccine, BNT162b2, ChAdOx1 nCoV-19, Inflammatory,