Abstract
The SARS-CoV-2 vaccine NVX-CoV2373 is a protein-based vaccine that might circumvent the difficulties in distributing mRNA vaccines to regions with limited access to cold-chain and refrigeration. However, the NVX-CoV2373-induced T cell and antibody responses remain poorly understood. In this issue of the JCI, Moderbacher et al. characterized SARS-CoV-2-specific CD4+ and CD8+ T cell responses elicited by one or two doses of NVX-CoV2373 in individuals enrolled in a phase I/IIa trial. Substantially increased spike-specific CD4+ and T follicular helper cells were found after the first or second vaccine dose, with some individuals developing a modest spike-specific CD8+ T cell response. Correlation analysis revealed an association between spike-specific CD4+ T cells and neutralizing antibody titers. Notably, preexisting T cell immunity showed negligible effects on NVX-CoV2373-induced T cell responses. These findings indicate that the protein-based vaccine NVX-CoV2373 induces robust T cell immunity capable of recognizing SARS-CoV-2 antigens and supporting humoral immune responses.
【초록키워드】 Vaccine, Trial, Immunity, mRNA vaccine, Antibody Response, SARS-CoV-2 vaccine, vaccine dose, T cell, Region, response, T cell responses, SARS-CoV-2 antigen, humoral immune responses, CD8+ T cell, CD4+ T cell, association, Analysis, dose, NVX-CoV2373, neutralizing antibody titers, individual, CD4+, Effect, Cell, robust, enrolled, characterized, induce, recognizing, elicited, circumvent, follicular, 【제목키워드】 Vaccine, Immunity, T cell, NVX-CoV2373, functional, elicit,