Abstract
A lack of confidence on the vaccination drive hinders the management of the COVID-19 pandemic. We aimed to assess the antibody response to the SARS-CoV-2 vaccine among hospitalized patients in China. This case-control study was based on SARS-CoV-2 sero-surveillance during hospitalization. From April to June 2021, hospitalized patients without documented COVID-19 infection from the Department of Urology were routinely assayed for anti-SARS-CoV-2 antibodies. The SARS-CoV-2 vaccination history of each participant was obtained from their vaccination records. Of the 405 participants, there were 37 seropositive participants (case group) and 368 seronegative participants (control group); 68 participants (16.8%) had received the inactivated SARS-CoV-2 vaccine, including 54 who received the Sinovac-CoronaVac vaccine and 14 received the Sinopharm vaccine. All seropositive participants who had received one or two doses of the SARS-CoV-2 vaccine were assessed for at least 16 days, while 31 (8.4%) of 368 seronegative controls who had received the vaccine were tested for 1-94 days. The overall seroconversion rate was 54.4% (37/68) in the vaccinated participants who received the inactivated SARS-CoV-2 vaccine. The odds ratio (OR) and confidence interval (CI) for seropositivity was 6.20 (95% CI: 2.05-18.71) in those received full vaccination with two doses versus those partially vaccinated participants with one dose after adjusting for sex and age. These findings imply that the inactivated SARS-CoV-2 vaccine could have a protective antibody response.
Keywords: China; SARS-CoV-2 vaccine; antibody response; case-control study; hospitalization.
【저자키워드】 Antibody Response, SARS-CoV-2 vaccine, China, case-control study, hospitalization., 【초록키워드】 SARS-CoV-2, Vaccine, vaccination, Hospitalization, antibody, COVID-19 pandemic, Sex, anti-SARS-CoV-2 antibodies, COVID-19 infection, management, Control, Case-control, age, Urology, seronegative, SARS-CoV-2 vaccination, inactivated, Protective, Sinopharm, dose, Odds ratio, confidence interval, Participants, participant, seroconversion rate, Department, tested, lack, hospitalized patient, the vaccine, the antibody response, was obtained, seronegative participant, seropositive participant, the SARS-CoV-2, were assessed, 【제목키워드】 hospitalized patient,