Abstract
It is important to determine if severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and SARS-CoV-2 mRNA vaccinations elicit different types of antibodies. Here, we characterize the magnitude and specificity of SARS-CoV-2 spike-reactive antibodies from 10 acutely infected health care workers with no prior SARS-CoV-2 exposure history and 23 participants who received SARS-CoV-2 mRNA vaccines. We found that infection and primary mRNA vaccination elicit S1- and S2-reactive antibodies, while secondary vaccination boosts mostly S1 antibodies. Using absorption assays, we found that SARS-CoV-2 infections elicit a large proportion of original antigenic sin-like antibodies that bind efficiently to the spike of common seasonal human coronaviruses but poorly to the spike of SARS-CoV-2. In converse, vaccination modestly boosts antibodies reactive to the spike of common seasonal human coronaviruses, and these antibodies cross-react more efficiently to the spike of SARS-CoV-2. Our data indicate that SARS-CoV-2 infections and mRNA vaccinations elicit fundamentally different antibody responses.
Keywords: CP: Immunology; SARS-CoV-2; antibodies; coronavirus; mRNA vaccines; original antigenic sin.
【저자키워드】 antibodies, SARS-CoV-2, coronavirus, mRNA vaccines, CP: Immunology, original antigenic sin., 【초록키워드】 mRNA vaccination, vaccination, antibody, SARS-COV-2 infection, Infection, specificity, mRNA, Health care worker, human coronaviruses, boost, acute respiratory syndrome, antigenic, participant, responses, reactive, human coronavirus, proportion, assays, determine, elicit, magnitude, cross-react, 【제목키워드】 mRNA vaccination, antibody, SARS-COV-2 infection, antigenic, elicit,