Abstract
The objective of our study was to evaluate the antibody responses of health care workers (HCWs) who were vaccinated with booster dose BNT162b2 6 months after 2 doses of the CoronoVac vaccine. The study included 318 HCWs vaccinated with inactive CoronaVac SARS-CoV-2 vaccine in 2 doses. Anti-spike/RBD IgG levels were measured immediately before and 1 month after the booster dose. In the sixth month after CoronaVac vaccination, the median of antibody levels of 1212.02 AU/ML, while it was 9283 AU/mL after BNT162b2 vaccination. IgG antibody titers of over 1050 AU/mL (which is equivalent to 1:80 dilution in the plaque reduction neutralization test) were detected in HCWs 15.09% and 97.8%, respectively. Our results showed that antibody titers increased 8-fold after the booster dose. We believe that the administration of the mRNA vaccine as a booster dose can provide more effective protection against COVID-19 infection, especially in individuals with risk factors.
Keywords: Antibody; BNT162b2; COVID-19; CoronaVac; Vaccine.
【저자키워드】 COVID-19, Vaccine, antibody, CoronaVac, BNT162b2, 【초록키워드】 Vaccine, vaccination, Risk factors, mRNA vaccine, SARS-CoV-2 vaccine, COVID-19 infection, HCWs, Antibody titer, Health care worker, booster dose, administration, dose, Dilution, IgG antibody titer, HCW, individual, doses, plaque reduction neutralization, effective, evaluate, inactive, the antibody response, were measured, IgG level, the median, 【제목키워드】 immune response, COVID-19 vaccination, booster, HCW, elicited,