Abstract
Background: We investigated the importance of lupus anticoagulant (LA) in patients with SARS-CoV-2. Methods: Medical records of 41 SARS-CoV-2 infected patients were reviewed. Patients were classified into two groups according to the frequency of positive LA test results: “LA (-)” and “LA (+) ≥1” (LA positive at least once). Statistical analysis was performed to determine the association between LA presence and change in LA test results and disease course according to both hospital days (HD) and days after diagnosis (DD). Results: The prevalence of LA was 51.2%. Averagely, the first change in LA test result occurred during DD 12-13 and between HD 9-10. The second change occurred on DD 15-16 and HD 13-14. The presence of LA was associated with severe disease ( P = .004) but was not associated with thrombotic complications or mortality. The change of results from negative to positive or vice versa or the frequency of the changes was not associated with disease severity, thrombotic complications, or mortality. Conclusions: LA positivity can be regarded as one of the findings suggesting more serious SARS-CoV-2 infection.
Keywords: COVID-19; SARS-CoV-2; lupus anticoagulant; mortality; thrombosis.
【저자키워드】 COVID-19, SARS-CoV-2, Mortality, thrombosis., lupus anticoagulant, 【초록키워드】 thrombosis, Thrombotic complications, SARS-COV-2 infection, disease severity, hospital, Diagnosis, Prevalence, change, association, Anticoagulant, Frequency, Analysis, severe disease, medical record, disease course, positive, thrombotic complication, occurred, investigated, was performed, determine, two group, patients with SARS-CoV-2, SARS-CoV-2 infected patient, 【제목키워드】 Lupus,