Abstract
The optimal SARS-CoV-2 vaccination schedule in dialysis patients and the potential need for a fourth vaccine dose are debatable. We prospectively assessed the humoral responses to three and four doses of BNT162b2 among dialysis patients. The study included 106 dialysis patients; 60 (56.6%) and 46 (43.4%) received 3 and 4 vaccine doses, respectively. Anti-spike (anti-S) antibody titers significantly increased after the third vaccine dose, followed by a decline, yet still remained higher than all previous measurements. The fourth vaccine dose led to another profound rise in anti-S titers. The absolute increase following the fourth dose correlated with response to the third dose. Infection risk however was similar between patients vaccinated with three or four doses.
Keywords: COVID-19; Hemodialysis; Humoral response; Vaccination.
【저자키워드】 COVID-19, vaccination., Hemodialysis, Humoral response, 【초록키워드】 vaccine doses, risk, dialysis, vaccine dose, Patient, Antibody titer, patients, SARS-CoV-2 vaccination, dose, absolute increase, doses, anti-S, significantly increased, remained, correlated, debatable, of BNT162b2, 【제목키워드】 SARS-CoV-2, BNT162b2, response,