Abstract
Several factors related to anti-spike(S) IgG antibody titers after mRNA COVID-19 vaccination have been elucidated, but the magnitude of the effects of each factor has not been fully understood. This cross-sectional study assessed anti-S and anti-nucleocapsid (N) antibody titers on 3744 healthy volunteers (median age, 36 years; IQR, 24-49 years; females, 59.0%) who received two doses of mRNA-1273 or BNT162b2 vaccine and completed a survey questionnaire. Multiple regression was conducted to identify factors associated with antibody titers. All but one participant tested positive for anti-S antibodies (99.97%). The following factors were independently and significantly associated with high antibody titer: < 3 months from vaccination (ratio of means 4.41); mRNA-1273 vaccine (1.90, vs BNT162b2); anti-N antibody positivity (1.62); age (10’s: 1.50, 20’s: 1.37, 30’s: 1.26, 40’s: 1.16, 50’s: 1.15, vs ≧60’s); female (1.07); immunosuppressive therapy (0.54); current smoking (0.85); and current drinking (0.96). The largest impact on anti-S IgG antibody titers was found in elapsed time after vaccination, followed by vaccine brand, immunosuppressants, previous SARS-CoV-2 infection (anti-N antibody positive), and age. Although the influence of adverse reactions after the vaccine, gender, smoking, and drinking was relatively small, they were independently related factors.
【초록키워드】 Vaccine, BNT162b2 vaccine, vaccination, therapy, antibody, mRNA-1273, cross-sectional, SARS-COV-2 infection, Gender, smoking, immunosuppressants, COVID-19 vaccination, mRNA, female, Antibody titer, Factors, age, questionnaire, Antibody titers, anti-S IgG, dose, Adverse reaction, immunosuppressive, IgG antibody titer, mRNA-1273 vaccine, Factor, median age, positive, anti-S, Multiple, anti-S antibody, Effect, females, tested, identify, significantly, conducted, magnitude, the vaccine, 1.26, elapsed, healthy volunteer, IQR, 【제목키워드】 COVID-19 vaccination, anti-Spike IgG, mRNA, Antibody titer, Japanese, Factor, Volunteer, healthy, affecting,