Abstract
Clinical microbiology has possessed a marvellous past, an important present and a bright future. Western medicine modernization started with the discovery of bacterial pathogens, and from then, clinical bacteriology became a cornerstone of diagnostics. Today, clinical microbiology uses standard techniques including Gram stain morphology, in vitro culture, antigen and antibody assays, and molecular biology both to establish a diagnosis and monitor the progression of microbial infections. Clinical microbiology has played a critical role in pathogen detection and characterization for emerging infectious diseases as evidenced by the ongoing COVID-19 pandemic. Revolutionary changes are on the way in clinical microbiology with the application of “-omic” techniques, including transcriptomics and metabolomics, and optimization of clinical practice configurations to improve outcomes of patients with infectious diseases.
Keywords: COVID-19; Clinical microbiology; genomics; metabolomics; nucleic acid amplification; point of care; proteomics; transcriptomics.
【저자키워드】 COVID-19, metabolomics, proteomics, point of care, Genomics, clinical microbiology, nucleic acid amplification, transcriptomics., 【초록키워드】 Diseases, Molecular biology, COVID-19 pandemic, transcriptomics, Diagnosis, Infectious disease, progression, in vitro, outcome, diagnostics, Antigen, nucleic acid, Culture, clinical, Patient, morphology, Bacterial pathogens, change, Critical, pathogen detection, Clinical practice, Antibody assays, MONITOR, microbial infections, IMPROVE, evidenced, Gram stain, Revolutionary, 【제목키워드】 clinical, microbial,