Abstract
Background: Concurrent detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and another respiratory virus in individuals can document contemporaneous circulation. We used an ongoing, community-based study of school-aged children and their households to evaluate SARS-CoV-2 codetections with other respiratory viruses in a non-medically attended population over a 2-year period.
Methods: Household enrollment was predicated on an acute respiratory illness in a child residing in that household who was also a kindergarten through 12th-grade student in the participating school district. Demographic, symptom, and household composition data and self-collected nasal specimens were obtained on the recruitment day, and 7 and 14 days later, from the index child and all other household members. All specimens were tested for SARS-CoV-2 and influenza A/B by reverse-transcription polymerase chain reaction. Day 0 specimens from the index children were simultaneously tested for 16 pathogens using a commercial respiratory pathogen panel (RPP). To assess viral codetections involving SARS-CoV-2, all household specimens were tested via RPP if the index child’s day 0 specimen tested positive to any of the 16 pathogen targets in RPP and any household member tested positive for SARS-CoV-2.
Results: Of 2109 participants (497 index children in 497 households with 1612 additional household members), 2 (0.1%) were positive for both SARS-CoV-2 and influenza A; an additional 11 (0.5%) were positive for SARS-CoV-2 and another RPP-covered respiratory virus. Codetections predominantly affected school-aged children (12 of 13 total) and were noted in 11 of 497 households.
Conclusions: SARS-CoV-2 codetections with other respiratory viruses were uncommon and predominated in school-aged children.
Keywords: SARS-CoV-2; children; codetection; households; respiratory viruses.
【저자키워드】 SARS-CoV-2, children, Households, codetection, respiratory viruses., 【초록키워드】 coronavirus, Influenza, nasal, Symptom, respiratory viruses, pathogen, household, respiratory virus, target, circulation, recruitment, demographic, acute respiratory syndrome, Enrollment, acute respiratory illness, respiratory pathogen, individual, specimen, participant, positive, another respiratory virus, concurrent, polymerase chain, tested, affected, evaluate, Day, other respiratory virus, 【제목키워드】 coronavirus 2, household, respiratory, Other,