Abstract
Background: Th-17 cells, a proinflammatory subset of CD4 T lymphocytes, have been suggested as a possible cause of coronavirus disease-19 (COVID-19)-related immunological injuries. The aim of this study was to investigate the relationship between IL-17F (rs763780) polymorphism and the susceptibility to and outcomes of COVID-19 infection and to determine the clinical and laboratory predictors of COVID-19 death.
Methods: This case-control study included 132 COVID-19 patients and 135 healthy age- and sex-matched controls. The participants were tested for IL-17F rs763780 polymorphism via TaqMan-based genotyping and for the expression of IL-17 by enzyme-linked immunosorbent assay. This study also investigated the predictors for COVID-19 mortality.
Results: A non-statistically significant association was observed between IL-17F alleles and genotypes with COVID-19 ( P =0.309, P =0.138, respectively). Moreover, no significant difference in the IL-17F genotypes was observed between non-survivors and survivors ( P =0.482). In the multivariate analysis, the participants with the following characteristics had 17.7-, 11.2-, 8-, and 17.9-fold higher odds of exhibiting in-hospital mortality, respectively: (1) hypertension, (2) age of >57 years, (3) WBC count of >12.6 × 10 3 /mm 3 , and (4) D-dimer of >0.9 ng/ml. The ROC curve analysis showed that IL-17 at a cutoff point of >46 pg/ml was a perfect discriminator of COVID-19 patients from control subjects (AUC = 1.0).
Conclusion: The findings indicate that the IL-17F H161R variant does not influence the risk of COVID-19. However, the IL-17 level is a perfect discriminator of COVID-19 infection. Hypertension, age of >57 years, white blood cell count of >12.6 × 10 3 /mm 3 , and D-dimer of >0.9 ng/ml are the independent predictors for death among COVID-19 patients.
【초록키워드】 COVID-19, susceptibility, variant, polymorphism, D-dimer, outcome, CD4, hypertension, Laboratory, proinflammatory, Characteristics, Coronavirus disease-19, White blood cell, COVID-19 infection, cells, Genotype, death, age, WBC, T lymphocytes, predictor, genotyping, expression, in-hospital mortality, COVID-19 patients, case-control study, association, Analysis, COVID-19 mortality, COVID-19 patient, ROC Curve, AUC, IL-17, no significant difference, participant, allele, survivor, cutoff point, risk of COVID-19, controls, non-survivor, enzyme-linked immunosorbent, tested, healthy, investigated, determine, suggested, subset, exhibiting, control subject, higher odd, immunological injuries, independent predictor, with COVID-19, 【제목키워드】 COVID-19,