Abstract
As SARS-CoV-2 and influenza viruses co-circulate, co-infections with these viruses generate an increasing concern to public health. To evaluate the prevalence and clinical impacts of SARS-CoV-2 and influenza A virus co-infections during the 2021-2022 influenza season, SARS-CoV-2-positive samples from 462 individuals were collected from October 2021 to January 2022. Of these individuals, 152 tested positive for influenza, and the monthly co-infection rate ranged from 7.1% to 48%. Compared to the Delta variant, individuals infected with Omicron were less likely to be co-infected and hospitalized, and individuals who received influenza vaccines were less likely to become co-infected. Three individuals had two samples collected on different dates, and all three developed a co-infection after their initial SARS-CoV-2 infection. This study demonstrates high prevalence of co-infections in central Missouri during the 2021-2022 influenza season, differences in co-infection prevalence between the Delta and the Omicron waves, and the importance of influenza vaccinations against co-infections.
Keywords: Co-infection; H3N2; Influenza a virus; Influenza vaccination; SARS-CoV-2; SARS-CoV-2 variant.
【저자키워드】 SARS-CoV-2, influenza A virus, Co-infection, SARS-CoV-2 variant., influenza vaccination, H3N2, 【초록키워드】 public health, vaccination, Hospitalized, Influenza, SARS-COV-2 infection, SARS-CoV-2 variant, Delta, omicron, delta variant, Prevalence, influenza vaccine, clinical impact, individual, positive, initial, tested, collected, evaluate, virus, generate, less, influenza virus, individuals, ranged, 【제목키워드】 Influenza, cross-sectional,