Abstract
We used unsupervised immunophenotyping of blood leukocytes and measured cytokine production by innate immune cell exposed to LPS and R848. We show that COVID-19 induces a rapid, transient upregulation of myeloid-derived suppressor cells (MDSCs) accompanied by a rapid, sustained (up to 3 months) hyporesponsiveness of dendritic cells and monocytes. Blood MDSCs may represent biomarkers and targets for intervention strategies in COVID-19 patients.
Keywords: COVID-19; Cytokines; Dendritic cells; Monocytes; Myeloid-derived suppressor cells.
All Keywords
【저자키워드】 COVID-19, Monocytes, Cytokines, dendritic cells, myeloid-derived suppressor cells., 【초록키워드】 Biomarker, Intervention, cells, target, dendritic cell, cytokine production, COVID-19 patients, LPS, upregulation, blood leukocyte, Cell, hyporesponsiveness, induce, sustained, accompanied, innate immune cell, 【제목키워드】 innate immune, dysfunction, increase,
【저자키워드】 COVID-19, Monocytes, Cytokines, dendritic cells, myeloid-derived suppressor cells., 【초록키워드】 Biomarker, Intervention, cells, target, dendritic cell, cytokine production, COVID-19 patients, LPS, upregulation, blood leukocyte, Cell, hyporesponsiveness, induce, sustained, accompanied, innate immune cell, 【제목키워드】 innate immune, dysfunction, increase,