Abstract
The aim of the study was to evaluate the levels of cardiac biomarkers endothelin 1, B-natriuretic peptide (BNP), N-terminal pro-B-type natriuretic peptide (Nt-proBNP), NO 2 , and NO 3 in patients with COVID-19 pneumonia and various degrees of pulmonary hypertension. Group 1 included patients with pulmonary artery systolic pressure <25 mm Hg, group 2 with 25-40 mm Hg, and group 3 with 40-60 mm Hg. In the group of patients with pulmonary artery systolic pressure <25 mm Hg, the level of NT-proBNP was higher than in the rest two groups by 41.3% (p=0.015) and 38.2% (p=0.015), respectively. The levels of nitrites and nitrates in group 1 patients were lower: NO 2 was reduced by 31.1% (p=0.026) and 62.8% (p=0.008), and NO 3 was reduced by 28% (p=0.029) and by 54.6% (p=0.006), respectively. No other changes in the parameters in patients receiving oxygen therapy were found. These findings suggest that severe course of COVID-19 in patients with severe pulmonary hypertension is associated with impaired nitrite and nitrate metabolism and reduced levels of Nt-proBNP.
Keywords: BNP; COVID-19; NO; NP-proBNP; pulmonary hypertension.
【저자키워드】 COVID-19, NO, BNP, pulmonary hypertension, NP-proBNP, 【초록키워드】 therapy, Biomarker, Pneumonia, peptide, metabolism, Patient, group, NT-proBNP, Nitrate, pulmonary hypertension, nitrite, parameter, N-terminal, Course, evaluate, reduced, changes in, two group, was reduced, COVID-19 in patient, patients receiving oxygen, patients with COVID-19, pro-B-type natriuretic peptide, 【제목키워드】 pulmonary, change, degree,