Abstract
Aim: The study investigated heparin-binding protein (HBP) levels in patients with severe COVID-19 pneumonia and their relation to prognosis. Methods: A total of 134 patients with serious COVID-19 pneumonia were prospectively analyzed. HBP levels were statistically compared between both the patient and healthy control groups and within the patient group itself. Results: HBP was defined to be significantly higher in the patient group compared with the control group. There was a statistically significant distinction between the patients who survived and those who died with regard to HBP levels. When the cutoff value of HBP was >13.47, sensitivity (89.8%), specificity (74.1%) had area under the curve values of 0.806 (p < 0.001). Conclusion: HBP level may be used for prognosis prediction of patients with COVID-19.
Keywords: COVID-19; biomarkers; diagnosis; emergency medicine; heparin-binding protein; infection; inflammation; mortality; pneumonia; prognosis.
【저자키워드】 COVID-19, Inflammation, Biomarkers, Mortality, Pneumonia, Infection, Diagnosis, emergency medicine, Prognosis., Heparin-binding protein, 【초록키워드】 Severe COVID-19 pneumonia, Prognosis, Protein, sensitivity, specificity, Patient, group, control group, healthy control, serious COVID-19, cutoff value, defined, analyzed, died, the patient, investigated, significantly higher, statistically significant, survived, statistically, patients with COVID-19, 【제목키워드】 Severe COVID-19 pneumonia, Protein,