Natural killer cells, one of the important types of innate immune cells, play a pivotal role in the antiviral process in vivo. It has been shown that increasing NK cell activity may promote the alleviation of viral infections, even severe infection-induced sepsis. Given the current state of the novel coronavirus (SARS-CoV-2) global pandemic, clarifying the anti-viral function of NK cells would be helpful for revealing the mechanism of host immune responses and decipher the progression of COVID-19 and providing important clues for combating this pandemic. In this review, we summarize the roles of NK cells in viral infection and sepsis as well as the potential possibilities of NK cell-based immunotherapy for treating COVID-19.
【저자키워드】 COVID-19, viral infection, Sepsis, Natural killer cells, 【초록키워드】 SARS-CoV-2, viral infection, Severe infection, pandemic, Antiviral, Immunotherapy, Infection, NK cell, NK cells, Sepsis, progression, viral infections, Novel coronavirus, Anti-viral, global pandemic, Viral, Host immune response, cells, immune responses, immune cells, Innate immune cells, Natural killer cells, in vivo, mechanism, natural, host immune responses, treating COVID-19, alleviation, combating, shown, in viral, promote, 【제목키워드】 Sepsis, virus infection,