Objectives: Comparative analysis of laboratory data in moderate-to-severe COVID-19 patients presenting with or without ground-glass opacities (GGOs). Methods: This retrospective study examined 61 patients with moderate-to-severe COVID-19, as defined by the report of the WHO-China Joint Mission on COVID-19. All patients were admitted to the Department of Infectious Diseases, Wuhan Union Hospital from Dec 28, 2019 to Feb 22, 2020 and classified into a GGO group or a non-GGO group based on CT results. The clinical characteristics and laboratory data of the two groups were compared. Data were analyzed using univariate and multivariate analysis, and using receiver operating characteristic (ROC) analysis. Results: Forty-five patients were in the GGO group (73.8%, 21 females, 24 males, mean age 54.8±17.8 years) and 16 were in the non-GGO group (26.2%, 11 females, 5 males, mean age 53±14.9 years). The levels of IL-2, IL-4, and IFN-γ were greater in the GGO group (all P<0.05). ROC analysis indicated that an elevated level of IL-2 was a good predictor of GGO (area under the curve: 0.716, optimal cutoff: 3.205 pg/mL, 53.8% sensitivity, 87.5% specificity, p<0.05). Multivariate analysis showed that IL-2 level was a significant and independent risk factor for lung GGO (OR: 8.167; 95% CI: 1.63, 40.8; P<0.05). Conclusions: There were correlations between GGO in the lungs of patients with moderate-to-severe COVID-19 and the levels of IL-2, IL-4, and INF-γ. IL-2 was a significant and independent risk factor for GGO. These findings provide a basis for studying the mechanism of pulmonary lesions in COVID-19 patients.
【저자키워드】 COVID-19, SARS-CoV-2, GGO, Moderate-to-severe, Inflammatory cytokines, Risk factors., 【초록키워드】 Infectious diseases, Clinical characteristics, lung, Retrospective study, ground-glass opacity, sensitivity, specificity, Ground-glass opacities, ROC, Comparative analysis, Lungs, Wuhan, Patient, age, correlation, characteristic, mechanism, COVID-19 patients, IFN-γ, IL-2, ROC analysis, Multivariate analysis, IL-4, Analysis, INF-γ, receiver operating characteristic, two groups, moderate-to-severe COVID-19, laboratory data, pulmonary lesions, correlations, independent risk factor, report, Department, moderate-to-severe COVID-19 patients, GGOs, Union Hospital, females, males, greater, defined, analyzed, examined, indicated, elevated, two group, presenting, pulmonary lesion, moderate-to-severe COVID-19 patient, 【제목키워드】 ground-glass opacity, Patient, Inflammatory cytokines, Inflammatory cytokine, moderate-to-severe COVID-19 pneumonia, pulmonary CT,