Abstract
Viral pathologies encompass activation of pro-oxidative pathways and inflammatory burst. Alleviating overproduction of reactive oxygen species and cytokine storm in COVID-19 is essential to counteract the immunogenic damage in endothelium and alveolar membranes. Antioxidants alleviate oxidative stress, cytokine storm, hyperinflammation, and diminish the risk of organ failure. Direct antiviral roles imply: impact on viral spike protein, interference with the ACE2 receptor, inhibition of dipeptidyl peptidase 4, transmembrane protease serine 2 or furin, and impact on of helicase, papain-like protease, 3-chyomotrypsin like protease, and RNA-dependent RNA polymerase. Prooxidative environment favors conformational changes in the receptor binding domain, promoting the affinity of the spike protein for the host receptor. Viral pathologies imply a vicious cycle, oxidative stress promoting inflammatory responses, and vice versa. The same was noticed with respect to the relationship antioxidant impairment-viral replication. Timing, dosage, pro-oxidative activities, mutual influences, and interference with other antioxidants should be carefully regarded. Deficiency is linked to illness severity.
【초록키워드】 COVID-19, pathology, Cytokine storm, Inflammatory responses, furin, ACE2 receptor, risk, protease, oxidative stress, antioxidant, Receptor binding domain, Endothelium, Dipeptidyl peptidase 4, Replication, Helicase, Papain-like protease, hyperinflammation, pathway, RNA-dependent RNA polymerase, Inflammatory, conformational change, Organ failure, Illness severity, viral spike protein, Activation, dosage, host receptor, activities, favor, transmembrane, immunogenic, membranes, influences, alveolar, vicious cycle, antiviral role, serine 2, Direct, the spike protein, reactive oxygen specy, alleviate, Alleviating, 【제목키워드】 role,