Abstract
Respiratory infections are the leading causes of mortality and the current pandemic COVID-19 is one such trauma that imposed catastrophic devastation to the health and economy of the world. Unravelling the correlations and interplay of the human microbiota in the gut-lung axis would offer incredible solutions to the underlying mystery of the disease progression. The study compared the microbiota profiles of six samples namely healthy gut, healthy lung, COVID-19 infected gut, COVID-19 infected lungs, Clostridium difficile infected gut and community-acquired pneumonia infected lungs. The metagenome data sets were processed, normalized, classified and the rarefaction curves were plotted. The microbial biomarkers for COVID-19 infections were identified as the abundance of Candida and Escherichia in lungs with Ruminococcus in the gut. Candida and Staphylococcus could play a vital role as putative prognostic biomarkers of community-acquired pneumonia whereas abundance of Faecalibacterium and Clostridium is associated with the C. difficile infections in gut. A machine learning random forest classifier applied to the data sets efficiently classified the biomarkers. The study offers an extensive and incredible understanding of the existence of gut-lung axis during dysbiosis of two anatomically different organs.
Keywords: diversity; gut-lung axis; interplay; microbiota; random forest classifier.
【저자키워드】 gut-lung axis, microbiota, random forest classifier., Diversity, interplay, 【초록키워드】 COVID-19, pandemic, Biomarker, Biomarkers, Mortality, Infection, lung, progression, Health, COVID-19 infection, Lungs, respiratory, correlation, trauma, community-acquired pneumonia, prognostic biomarker, Candida, Gut, Staphylococcus, microbial, Clostridium difficile, data set, Classifier, profile, organs, random, Clostridium, offer, metagenome, catastrophic, Faecalibacterium, healthy, the disease, applied, cause, processed, Escherichia, normalized, the gut-lung axis, 【제목키워드】 COVID-19, Biomarker, Infection, community-acquired pneumonia, microbial, Clostridium difficile,