Pneumonia caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is spreading globally. There have been strenuous efforts to reveal the mechanisms that the host defends itself against invasion by this virus. The immune system could play a crucial role in virus infection. Dendritic cell as sentinel of the immune system plays an irreplaceable role. Dendritic cells-based therapeutic approach may be a potential strategy for SARS-CoV-2 infection. In this review, the characteristics of coronavirus are described briefly. We focus on the essential functions of dendritic cell in severe SARS-CoV-2 infection. Basis of treatment based dendritic cells to combat coronavirus infections is summarized. Finally, we propose that the combination of DCs based vaccine and other therapy is worth further study.
【저자키워드】 Immunotherapy, dendritic cells (DCs) vaccine, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, immune system response, therapeutic vaccine, 【초록키워드】 Treatment, severe acute respiratory syndrome coronavirus 2, SARS-CoV-2, Coronavirus infection, Vaccine, coronavirus, therapy, Pneumonia, SARS-COV-2 infection, Infection, immune system, severe acute respiratory syndrome Coronavirus, virus, coronavirus 2, dendritic cells, Coronavirus infections, Characteristics, virus infection, respiratory, sentinel, mechanism, dendritic cell, function, Combination, Therapeutic approach, Invasion, focus, acute respiratory syndrome coronavirus, effort, severe SARS, Host, Cell, severe SARS-CoV-2, described, caused, Basis, defend, 【제목키워드】 Infection, severe SARS-CoV-2,