Abstract
In late 2019, a novel betacoronavirus, later termed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was discovered in patients with an unknown respiratory illness in Wuhan, China. SARS-CoV-2 and the disease caused by the novel coronavirus, coronavirus disease 2019 (COVID-19), spread rapidly and resulted in the World Health Organization declaring a pandemic in March 2020. In a minority of patients infected with SARS-CoV-2, severe illness develops characterized by a dysregulated immune response, acute respiratory distress syndrome, and multisystem organ failure. Despite the development of antiviral and multiple immunomodulatory therapies, outcomes of severe illness remain poor. In response, the Food and Drug Administration in the United States authorized the emergency use of several extracorporeal blood purification (EBP) devices for critically ill patients with COVID-19. Extracorporeal blood purification devices target various aspects of the host response to infection to reduce immune dysregulation. This review highlights the underlying technology, currently available literature on use in critically ill COVID-19 patients, and future studies involving four EBP platforms: 1) oXiris filter, 2) CytoSorb filter, 3) Seraph 100 Microbind blood affinity filter, and 4) the Spectra Optia Apheresis System with the Depuro D2000 Adsorption Cartridge.
【초록키워드】 COVID-19, coronavirus disease, SARS-CoV-2, coronavirus, pandemic, Antiviral, Infection, Respiratory illness, host response, drug, outcome, Novel coronavirus, Spread, Critically ill, Patient, COVID-19 patients, Blood, Emergency use, Blood purification, acute respiratory distress, food, immune dysregulation, Immunomodulatory therapies, World Health Organization, Critically ill patient, acute respiratory syndrome, novel Betacoronavirus, syndrome, dysregulated immune response, apheresis, Multisystem organ failure, System, extracorporeal blood purification, highlight, Wuhan, China, Seraph, develop, caused, the United State, the disease, characterized, reduce, EBP, infected with SARS-CoV-2, with COVID-19, 【제목키워드】 review, Extracorporeal, technique, Ill,