Abstract
COVID-19 (Coronavirus Disease 2019), a life-threatening viral infection, is caused by a highly pathogenic virus named SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2). Currently, no treatment is available for COVID-19; hence there is an urgent need to find effective therapeutic drugs to combat COVID-19 pandemic. Considering the fact that the world is facing a major issue of antimicrobial drug resistance, naturally occurring compounds have the potential to achieve this goal. Antimicrobial peptides (AMPs) are naturally occurring antimicrobial agents which are effective against a wide variety of microbial infections. Therefore, the use of AMPs is an attractive therapeutic strategy for the treatment of SARS-CoV-2 infection. This review sheds light on the potential of antimicrobial peptides as antiviral agents followed by a comprehensive description of effective antiviral peptides derived from various natural sources found to be effective against SARS-CoV and other respiratory viruses. It also highlights the mechanisms of action of antiviral peptides with special emphasis on their effectiveness against SARS-CoV-2 infection.
Keywords: Antimicrobial peptide; Antimicrobial resistance; Antiviral peptides; Severe acute respiratory syndrome coronavirus.
【저자키워드】 antimicrobial resistance, antiviral peptides, antimicrobial peptide, Severe acute respiratory syndrome coronavirus., 【초록키워드】 COVID-19, Treatment, SARS-CoV-2, viral infection, coronavirus, Antiviral, SARS-COV-2 infection, COVID-19 pandemic, peptide, virus, coronavirus 2, antimicrobial, Effectiveness, drug resistance, respiratory, antiviral agent, mechanism, therapeutic strategy, acute respiratory syndrome, Compound, life-threatening, AMPs, microbial infections, highly pathogenic, AMP, effective, highlight, antimicrobial agent, caused, variety, against SARS-CoV, therapeutic drug, 【제목키워드】 antimicrobial,