Abstract
Objectives: Coronavirus-disease-19 (COVID-19) continues to affect millions of individuals worldwide. Antiviral activity of mouthrinses remains an important research area as the oral cavity is a site of SARS-CoV-2 initial replication. The aim of this study was to assess the effectiveness of three different mouthrinses in reducing the oral/oropharyngeal SARS-CoV-2 viral load.
Methods: Adult patients, hospitalized with confirmed COVID-19 were recruited for the study. Oral/oropharyngeal baseline SARS-CoV-2 samples were collected and analyzed by Real-Time-PCR. Subsequently, patients were instructed to rinse with 1 % hydrogen peroxide (H 2 O 2 ), 0.12 % chlorhexidine (CHX), 1 % povidone‑iodine (PVP-I) or Sodium Chloride 0.9 % (placebo). Viral loads were measured right after (T1), and at 45 min (T2) from the rinse.
Results: In the PVP-I 1 % group, 5/8 (62.5 %) patients at T1, and 3/8 (37.5 %) patients at T2, SARS-CoV-2 was not detectable in the swab specimens. In the H 2 O 2 1 % group, 2/11 (18.2 %) patients at T1, and 2/11 (18.2 %) other patients at T2 showed no SARS-CoV-2 loads. One (12.5 %) patient in the CHX 0.12 % group showed SARS-CoV-2 negativity at T2. One (9.1 %) patient at T1, and another (9.1 %) patient at T2 showed no SARS-CoV-2 loads in the placebo group.
Conclusions: Oral SARS-CoV-2 loads were reduced at T1 in the PVP-I 1 % and H 2 O 2 1 % groups.
Clinical relevance: PVP-I 1 % was the most effective rinse especially in patients with low viral copy numbers at baseline.
Keywords: COVID-19; Chlorhexidine; Disinfection; Mouth; Oral cavity; Oral diseases; Oral medicine; Oral rinses; Povidone‑iodine; Public health; Saliva.
【저자키워드】 COVID-19, public health, Disinfection, chlorhexidine, Saliva., Oral diseases, Oral medicine, oral cavity, mouth, Povidone‑iodine, Oral rinses, 【초록키워드】 SARS-CoV-2, Hospitalized, Replication, clinical, Research, Patient, Effectiveness, Placebo, oral, hydrogen peroxide, swab specimens, Adult patients, individual, SARS-CoV-2 viral load, negativity, Affect, Public, effective, initial, analyzed, collected, recruited, detectable, reduced, reducing, groups, were measured, baseline, the placebo group, viral copy number, 【제목키워드】 Randomized, placebo-controlled, pilot study,