Abstract
Background: Tripartite motif-containing 28 (TRIM28) is an impressive regulator of the epigenetic control of the antiviral immune response. This study evaluated if the differential expression of TRIM28 correlates with the severity of coronavirus disease 2019 (COVID-19) infection.
Methods: A total of 330 COVID-19 patients, including 188 mild and 142 severe infections, and 160 healthy controls were enrolled in this study. Quantitative real-time polymerase chain reaction (qPCR) was used to determine the expression levels of TRIM28 in the studied patients.
Results: TRIM28 mRNA levels were significantly lower in both groups of patients versus the control group and in the severe group indicated further reduction in comparison to mild infection. The multivariate logistic regression analysis showed the mean age, lower levels of low-density lipoprotein (LDL), high-density lipoprotein (HDL), cholesterol, lower 25-hydroxyvitamin D, and PCR cycle threshold (Ct) value and higher levels of erythrocyte sedimentation rate (ESR) and differential expression of TRIM28 were linked to the severity of COVID-19 infection.
Conclusion: The results of this study proved that the downregulation of TRIM28 might be associated with the severity of COVID-19 infection. Further studies are required to determine the association between the COVID-19 infection severity and TRIM family proteins.
Keywords: Coronavirus disease 2019; Mild infection; Severe infection; Tripartite motif containing 28.
【저자키워드】 Coronavirus disease 2019, Severe infection, mild infection, Tripartite motif containing 28., 【초록키워드】 COVID-19, coronavirus disease, 25-hydroxyvitamin D, severity, Infection, Proteins, COVID-19 infection, severity of COVID-19, qPCR, Patient, Mild, age, ESR, cholesterol, threshold, disease, Epigenetic, patients, COVID-19 patients, association, HDL, LDL, Analysis, antiviral immune response, erythrocyte sedimentation rate, control group, differential expression, expression level, healthy control, severe group, multivariate logistic regression, severe infections, low-density, downregulation, motif, significantly lower, mRNA level, high-density, TRIM28, polymerase chain, PCR cycle, enrolled, was used, indicated, evaluated, required, determine, reduction in, the mean, in both group, 【제목키워드】 Mild, Severe COVID-19 Infection, expression level, Tripartite Motif,