Abstract
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is a complex disease which immune response can be more or less potent. In severe cases, patients might experience a cytokine storm that compromises their vital functions and impedes clearance of the infection. Gamma delta (γδ) T lymphocytes have a critical role initiating innate immunity and shaping adaptive immune responses, and they are recognized for their contribution to tumor surveillance, fighting infectious diseases, and autoimmunity. γδ T cells exist as both circulating T lymphocytes and as resident cells in different mucosal tissues, including the lungs and their critical role in other respiratory viral infections has been demonstrated. In the context of SARS-CoV-2 infection, γδ T cell responses are understudied. This review summarizes the findings on the antiviral role of γδ T cells in COVID-19, providing insight into how they may contribute to the control of infection in the mild/moderate clinical outcome.
Keywords: COVID-19; SARS-CoV-2; aminobisphosphonates COVID-19; gamma delta (γδ) T cells; innate immunity.
【저자키워드】 COVID-19, SARS-CoV-2, innate immunity., gamma delta (γδ) T cells, aminobisphosphonates COVID-19, 【초록키워드】 Autoimmunity, Coronavirus disease 2019, Cytokine storm, coronavirus, immune response, Diseases, Innate immunity, SARS-COV-2 infection, Infection, lung, Clinical outcome, T cell, Surveillance, Patient, severe cases, Gamma, disease, Critical, T cell response, respiratory viral infection, function, adaptive immune responses, acute respiratory syndrome, complex, T lymphocyte, circulating, clearance, mucosal tissues, antiviral role, Cell, caused, less, contribute, demonstrated, impede, 【제목키워드】 T cell, insight,