Abstract
The recently discovered truncated, non-functional, ACE2 transcript (dACE2), but not the full-length ACE2 (f-lACE2), is induced by IFNs in differentiated airway cells. We measured expression of both ACE2 isoforms in SARS-CoV-2 positive and negative subjects, in relation to Interferon-stimulated genes. A significant activation of dACE2 transcript was found, in SARS-CoV-2 positive adults either hospitalized or not, showing a positive correlation with ISG15; f-lACE2 expression was weakly activated and not ISG-related. We confirmed a specific activation of dACE2 transcript in nasopharyngeal cells, related to the mucosal IFN response.
Keywords: ACE2; COVID-19; Interferon, ISG15; SARS-CoV-2; deleted ACE2.
【저자키워드】 COVID-19, SARS-CoV-2, ACE2, deleted ACE2., Interferon, ISG15, 【초록키워드】 Hospitalized, airway, cells, IFN, expression, mucosal, IFN response, Activation, positive correlation, positive, full-length, nasopharyngeal cells, transcript, isoform, Genes, activated, subjects, deleted, 【제목키워드】 receptor, interferon-stimulated gene, isoform, the SARS-CoV-2,