Abstract
Microfluidic resistive pulse sensing (MRPS) was used to determine the size -distribution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) based on detecting nearly 30,000 single virions. However, the ultrastructure of SARS-CoV-2 is thoroughly described, but ensemble properties of SARS-CoV-2, e.g., its particle size distribution, are sparsely reported. According to the MRPS results, the size distribution of SARS-CoV-2 follows a log-normal function with a mean value of 85.1 nm, which corresponds to an approximate diameter of the viral envelope. This result also confirms the low number (< 50) of spike proteins on the surface of the virions.
Keywords: Resistive pulse sensing; SARS-CoV-2; Size distribution; Spike protein; Viral envelope.
【저자키워드】 SARS-CoV-2, Spike protein, size distribution, Viral envelope., Resistive pulse sensing, 【초록키워드】 coronavirus, spike, distribution, ultrastructure, acute respiratory syndrome, mean value, pulse, virions, viral envelope, particle size distribution, described, was used, reported, determine, 【제목키워드】 pulse, SARS-CoV-2 virion,