Abstract
Introduction: Cancer patients with SARS-CoV-2 infection can experience a broad range of clinical manifestations and outcomes. Previous studies have demonstrated an association between torque teno virus (TTV) load and deficiencies of the immune system. The impact of SARS-CoV-2 and TTV viral loads in cancer patients is unknown.
Methods: In this retrospective study, 157 cancer patients and 191 noncancer controls were analysed for SARS-CoV-2 RNA and TTV DNA presence.
Results: SARS-CoV-2 RNA was detected in 66.2% of cancer patients and in 68.6% of noncancer control subjects. In SARS-CoV-2-positive patients, TTV was detectable in 79.8% of cancer patients, while in controls, TTV was detected in 71.7% of subjects. No statistically significant correlation was found between TTV and SARS-CoV-2 loads in cancer patients. However, the 100-day survival rate in cancer patients who died from COVID-19 was significantly lower in the TTV-positive group than in the TTV-negative group (P = 0.0475). In the cancer TTV-positive group, those who died also had a higher load of TTV than those who did not die (P = 0.0097).
Conclusions: Our findings indicated that the presence of TTV in nasopharyngeal swabs from cancer patients was related to a higher number of deaths from COVID-19 and to a higher TTV DNA load.
Keywords: Cancer; SARS-CoV-2; Torque teno virus.
【저자키워드】 SARS-CoV-2, Cancer, Torque teno virus., 【초록키워드】 COVID-19, Infection, immune system, virus, outcomes, Retrospective study, Nasopharyngeal swab, DNA, Viral load, Cancer patients, Control, death, SARS-CoV-2 RNA, survival rate, correlation, association, cancer patient, clinical manifestation, torque, deficiency, control subjects, SARS-CoV-2-positive patients, previous study, significantly lower, controls, died, indicated, detectable, analysed, subjects, demonstrated, statistically significant, patients with SARS-CoV-2, was related, 【제목키워드】 progression, virus, SARS-CoV-2 disease, Can,