Abstract
Miniaturization of biosensors has become an imperative demand because of its great potential in in vivo biomarker detection and disease diagnostics as well as the point-of-care testing for coping with public health crisis, such as the coronavirus disease 2019 pandemic. Here, we present an ultraminiature optical fiber-tip biosensor based on the plasmonic gold nanoparticles (AuNPs) directly printed upon the end face of a standard multimode optical fiber at visible light range. An in-situ precision photoreduction technology is developed to additively print the micropatterns of size-controlled AuNPs. The AuNPs reveal distinct localized surface plasmon resonance, whose peak wavelength provides an ideal spectral signal for label-free biodetection. The fabricated optical fiber-tip plasmonic biosensor can not only detect antibody, but also test SARS-CoV-2 mimetic DNA sequence at the concentration level of 0.8 pM. Such an ultraminiature fiber-tip plasmonic biosensor offers a cost-effective biodetection technology for a myriad of applications ranging from point-of-care testing to in vivo diagnosis of stubborn diseases.
Keywords: Additive printing; Gold nanoparticles; Optical fiber sensors; Plasmonic biosensor; Precision photoreduction.
【저자키워드】 Gold nanoparticles, optical fiber sensors, Precision photoreduction., Plasmonic biosensor, Additive printing, 【초록키워드】 coronavirus disease, SARS-CoV-2, pandemic, Biomarker, Diseases, antibody, Diagnosis, public health crisis, diagnostics, point-of-care, gold, optical, in vivo, disease, Optical fiber, Gold nanoparticle, miniaturization, Concentration, Precision, DNA sequence, offer, AuNP, fiber, Additive, detect, provide, imperative, 【제목키워드】 optical,