Abstract
Over the past two years, SARS-CoV-2 (Severe Acute Respiratory Syndrome-Coronavirus 2) infection has spread globally causing multi-organ disease and severely impacting the healthcare systems of all countries. Accordingly, the development of easy-to-access diagnostic devices has become essential to limit the effect of the virus worldwide. Real-Time PCR is considered the gold standard to identify SARS-CoV-2 infection due to high sensitivity, affordability, and capacity to detect low viral loads at early disease stage. Advances in lab on a chip technology has led to the development of some Point-of-Care (POC) devices using Real-Time PCR and approved by the United States Food and Drug Administration. We provide an overview on recently developed POC tests for the rapid diagnosis of COVID-19 infection. Practical applications of miniaturized devices based on viral genome amplification as well as favorable features such as reduced sample processing time, ease of use by non-specialized personnel, and the potential of PCR-based POC technologies will be highlighted and reviewed.
Keywords: Lab On Chip; Molecular Biology; Point of Care; Real-Time PCR; SARS-CoV-2; Viral infection.
【저자키워드】 SARS-CoV-2, Molecular biology, point of care, Viral infection., Real-time PCR, Lab On Chip, 【초록키워드】 SARS-COV-2 infection, POC, Infection, diagnostic, drug, virus, Spread, amplification, sensitivity, PCR, Viral load, respiratory, disease, food, viral genome, Healthcare system, POC test, gold standard, disease stage, advance, over, lab, feature, limit, identify, detect, the United State, approved, reduced, diagnosis of COVID-19, Point, 【제목키워드】 SARS-CoV-2 detection, PCR,