Abstract
Background: Coronavirus disease 2019 (COVID-19) is a potentially fatal pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), especially those of novel SARS-CoV-2 variants and infection has affected over 700 million people globally.
Methods: This retrospective, descriptive study included 118 patients admitted with SARS-CoV-2 infection as confirmed by real-time reverse transcription polymerase chain reaction.
Results: The median duration of detectable SARS-CoV-2 infection in patients with high ALT, AST, and PLT/LYMPH, or low CD4+, CD8+, and PLT/MONO was considerably longer. In the risk factor model, multivariate analysis was performed for the estimation of ALT (HR, 0.54; 95% CI, 0.36-0.81), AST (HR, 0.56; 95% CI, 0.34-0.93), CD4+ (HR,0.77; 95% CI, 0.48-1.24), CD8+ (HR,0.64; 95% CI, 0.37-1.11), PLT/LYMPH (HR, 1.16; 95% CI, 0.76-1.77), and PLT/MONO (HR, 0.64; 95% CI, 0.43-0.94).
Conclusions: The longer viral RNA duration was associated with a higher International Prognostic Index score ( p = 0.0013), demonstrating for the first time that multivariate features of the bioindicators closely associated with SARS-CoV-2-infected patients clear the virus.
【초록키워드】 COVID-19, SARS-CoV-2, Coronavirus disease 2019, coronavirus, Pneumonia, SARS-COV-2 infection, SARS-CoV-2 variant, Infection, risk factor, virus, Patient, AST, reverse transcription, Viral RNA, ALT, retrospective, Analysis, index, acute respiratory syndrome, 95% CI, CD4+, CD8+, feature, polymerase chain, affected, caused, detectable, was performed, median, SARS-CoV-2-infected patient, 【제목키워드】 COVID-19, dynamic,