Abstract
Sensitive and accurate detection of SARS-CoV-2 methods is meaningful for preventing and controlling the novel coronavirus. The detection techniques supporting portable, onsite, in-time, and online data transfer are urgently needed. Here, we one-click investigated the shape influence of silver nanostructures on SERS performance and their applications in the sensitive detection of SARS-CoV-2. Such investigation is achieved by adjusting multiple parameters (concentration, potential, and time) on the integrated electrochemical array, thus various morphologies (e.g., bulk, dendritic, globular, and spiky) can be one-click synthesized. The SERS performance results indicated that dendritic nanostructures are superior to the other three with an order of magnitude signal enhancement. Such on-electrode dendritic silver substrate also represents high sensitivity (LOD = 7.42 × 10 -14 M) and high reproducibility (RSD = 3.67%) toward the SARS-CoV-2 RNA sequence detection. Such approach provides great potentials for rapid diagnosis and prevention of diverse infectious diseases.
Keywords: Ag nanostructure; COVID-19; Microdroplets array; Mini-pillar platform; SERS.
【저자키워드】 COVID-19, SERS., Mini-pillar platform, Microdroplets array, Ag nanostructure, 【초록키워드】 SARS-CoV-2, Diseases, Diagnosis, Novel coronavirus, sensitivity, morphology, sensitive, Concentration, transfer, dendritic, reproducibility, RNA sequence, approach, indicated, investigated, provide, magnitude, multiple parameter, the SARS-CoV-2,