Abstract
The foremost concerns of COVID-19 vaccines are safety and efficacy, which becomes grave in countries with a high burden of Neglected Tropical Diseases. Studies proposed helminthic infections might alleviate the efficacy of COVID-19 vaccines. We share preliminary evidence on the association between filariasis and COVID-19 infection. We collated 2 ml of blood from 174 participants residing in filariasis endemic area. To determine filarial antigen, the Og4C3 test and for COVID-19 antibodies, tests through ELISA was performed. COVID-19 antibodies were present among 74/174 (42.5%), whereas filarial antigens were detected in 24/174 (13.8%) participants. An insignificant association [OR = 0.855 (0.36-2.034)] between two was observed. Hence, people in filarial endemic regions can continue taking vaccines without worrying about their efficacy due to the helminthic load in community.
Keywords: COVID-19; Lymphatic filariasis; Odisha; immunology; vaccine.
【저자키워드】 COVID-19, immunology, vaccine., lymphatic filariasis, odisha, 【초록키워드】 antibodies, Efficacy, Vaccine, COVID-19 vaccine, Infection, ELISA, Antigen, COVID-19 vaccines, Region, COVID-19 infection, Community, COVID-19 antibody, Blood, association, Evidence, Endemic, Participants, participant, country, endemic area, was performed, determine, alleviate, Lymphatic, Neglected, 【제목키워드】 Evidence, Interaction, immunological,