Abstract
Over the last three years, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related health crisis has claimed over six million lives and caused USD 12 trillion losses to the global economy. SARS-CoV-2 continuously mutates and evolves with a high basic reproduction number (R0), resulting in a variety of clinical manifestations ranging from asymptomatic infection to acute respiratory distress syndrome (ARDS) and even death. To gain a better understanding of coronavirus disease 2019 (COVID-19), it is critical to investigate the components that cause various clinical manifestations. Single-cell sequencing has substantial advantages in terms of identifying differentially expressed genes among individual cells, which can provide a better understanding of the various physiological and pathological processes. This article reviewed the use of single-cell transcriptomics in COVID-19 research, examined the immune response disparities generated by SARS-CoV-2, and offered insights regarding how to improve COVID-19 diagnosis and treatment plans.
Keywords: COVID-19; SARS-CoV-2; immune response; single-cell transcriptomics.
【저자키워드】 COVID-19, SARS-CoV-2, immune response, Single-cell transcriptomics., 【초록키워드】 Treatment, coronavirus disease, ARDS, coronavirus, Sequencing, transcriptomics, immune, clinical manifestations, Health, COVID-19 diagnosis, asymptomatic infection, death, basic reproduction number, Critical, single-cell, differentially expressed gene, acute respiratory distress, physiological, clinical manifestation, acute respiratory syndrome, syndrome, component, COVID-19 research, individual cells, over, IMPROVE, resulting, examined, caused, variety, mutate, claimed, offered, 【제목키워드】 application, development,