Abstract
Since the emergence and rapid transmission of SARS-CoV-2, numerous scientific reports have searched for the association of host genetic variants with COVID-19, but the data are mostly acquired from Europe. In the current work, we explored the link between host genes (SARS-CoV-2 entry and immune system related to COVID-19 sensitivity/severity) and ABO blood types with COVID-19 from whole-exome data of 200 COVID-19 patients and 100 controls in Vietnam. The O blood type was found to be a protective factor that weakens the worst outcomes of infected individuals. For SARS-CoV-2 susceptibility, rs2229207 (TC genotype, allele C) and rs17860118 (allele T) of IFNAR2 increased the risk of infection, but rs139940581 (CT genotype, allele T) of SLC6A20 reduced virus sensitivity. For COVID-19 progress, the frequencies of rs4622692 (TG genotype) and rs1048610 (TC genotype) of ADAM17 were significantly higher in the moderate group than in the severe/fatal group. The variant rs12329760 (AA genotype) of TMPRSS2 was significantly associated with asymptomatic/mild symptoms. Additionally, rs2304255 (CT genotype, allele T) of TYK2 and rs2277735 (AG genotype) of DPP9 were associated with severe/fatal outcomes. Studies on different populations will give better insights into the pathogenesis, which is ethnic-dependent, and thus decipher the genetic factor’s contribution to mechanisms that predispose people to being more vulnerable to COVID-19.
Keywords: ABO blood type; COVID-19; SARS-CoV-2; host genetic variants; whole-exome sequencing.
【저자키워드】 COVID-19, SARS-CoV-2, whole-exome sequencing., ABO blood type, host genetic variants, 【초록키워드】 TMPRSS2, Europe, Pathogenesis, Genetic, whole-exome sequencing, variant, Infection, immune system, outcome, virus, Symptoms, Population, outcomes, sensitivity, Genotype, Control, ADAM17, Genetic variant, moderate, mechanism, Blood, association, IFNAR2, Frequency, ABO, COVID-19 patient, DPP9, SARS-CoV-2 entry, infected individuals, SARS-CoV-2 susceptibility, protective factor, allele, transmission of SARS-CoV-2, SLC6A20, Host, TYK2, significantly, reduced, searched, significantly higher, host gene, increased the risk, whole-exome data, with COVID-19, 【제목키워드】 Factor, with COVID-19,