Abstract
Alzheimer’s disease (AD)-like cognitive impairment, a kind of Neuro-COVID syndrome, is a reported complication of SARS-CoV-2 infection. However, the specific mechanisms remain largely unknown. Here, we integrated single-nucleus RNA-sequencing data to explore the potential shared genes and pathways that may lead to cognitive dysfunction in AD and COVID-19. We also constructed ingenuity AD-high-risk scores based on AD-high-risk genes from transcriptomic, proteomic, and Genome-Wide Association Studies (GWAS) data to identify disease-associated cell subtypes and potential targets in COVID-19 patients. We demonstrated that the primary disturbed cell populations were astrocytes and neurons between the above two dis-eases that exhibit cognitive impairment. We identified significant relationships between COVID-19 and AD involving synaptic dysfunction, neuronal damage, and neuroinflammation. Our findings may provide new insight for future studies to identify novel targets for preventive and therapeutic interventions in COVID-19 patients.
Keywords: AD-high-risk scores; Alzheimer’s disease; SARS-CoV-2; cognitive impairment; neuroinflammation; single-nucleus RNA sequencing.
【저자키워드】 SARS-CoV-2, Alzheimer’s disease, Neuroinflammation, Cognitive impairment, single-nucleus RNA sequencing., AD-high-risk scores, 【초록키워드】 COVID-19, SARS-COV-2 infection, RNA sequencing, pathway, target, GWAS, Astrocyte, disease, mechanism, proteomic, RNA-sequencing, COVID-19 patients, Neuron, dysfunction, cognitive, syndrome, therapeutic intervention, subtype, cell population, transcriptomic, Cell, identify, reported, demonstrated, disease-associated, neuronal, synaptic, 【제목키워드】 COVID-19, RNA sequencing, disease, mechanism, reveal,