Abstract
At the end of 2019, the COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection, seriously damaged world public health security. Several protein markers associated with virus infection have been extensively explored to combat the ever-increasing challenge posed by SARS-CoV-2. The proteomics of COVID-19 deepened our understanding of viral particles and their mechanisms of host invasion, providing us with information on protein changes in host tissues, cells and body fluids following infection in COVID-19 patients. In this review, we summarize the proteomic studies of SARS-CoV-2 infection and review the current understanding of COVID-19 in terms of the quantitative and qualitative proteomics of viral particles and host entry factors from the perspective of protein pathological changes in the organism following host infection.
Keywords: COVID-19; SARS-CoV-2; protein biomarker; proteomics; virus infection.
【저자키워드】 COVID-19, SARS-CoV-2, proteomics, virus infection., protein biomarker, 【초록키워드】 public health, coronavirus, SARS-COV-2 infection, COVID-19 pandemic, Infection, Protein, virus infection, information, Quantitative, mechanism, COVID-19 patients, marker, Invasion, body fluid, acute respiratory syndrome, Factor, tissues, Perspective, organism, host infection, viral particle, Host, Cell, proteomic study, caused, changes in, pathological change, damaged, 【제목키워드】 therapy, SARS-COV-2 infection, Diagnosis, mechanisms, prognostic,