Abstract
Hesperetin, mainly found in citrus honey, has antioxidant, anti-inflammatory, and antiviral properties. Recently, the effect of hesperetin on different aspects of SARS-CoV-2 infection such as viral entry, replication, and inflammatory responses has attracted a lot of attention. However, the exact molecular mechanism for its effects on SARS-CoV-2 infection is not stated. The PI3K/AKT signaling pathway is an intracellular pathway involved in cell proliferation, protein synthesis, and response to environmental changes. Since the role of this pathway in the pathogenesis of SARS-CoV-2 has recently been considered, this letter assumes the probable role of this pathway in the function of hesperetin against SARS-CoV-2 infection. PRACTICAL APPLICATIONS: In this paper, we have discussed the therapeutic effects of hesperetin on SARS-CoV-2 infection. Additionally, we have hypothesized the molecular mechanism of hesperetin in suppression of SARS-CoV-2 entry to the host cells, its replication and inhibition of inflammatory responses. Based on this evidence, the pharmacological properties of hesperetin make this natural compound a potential treatment for suppression of SARS-CoV-2 entry into host cells and the subsequent replication of viral particles.
Keywords: COVID-19; PI3K/AKT; SARS-CoV-2; hesperetin.
【저자키워드】 COVID-19, SARS-CoV-2, PI3K/AKT, hesperetin., 【초록키워드】 Inflammatory responses, Anti-inflammatory, SARS-COV-2 infection, molecular mechanism, antioxidant, viral entry, Replication, pathway, signaling pathway, Evidence, Inflammatory response, protein synthesis, Potential treatment, Viral particles, cell proliferation, host cells, host cell, changes, hesperetin, SARS-CoV-2 entry, antiviral properties, therapeutic effect, pathogenesis of SARS-CoV-2, pharmacological, Effect, involved, subsequent, 【제목키워드】 Replication, Interaction,