Abstract
Coronavirus Disease 2019 (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to considerable morbidity and mortality worldwide. The clinical manifestation of COVID-19 ranges from asymptomatic or mild infection to severe or critical illness, such as respiratory failure, multi-organ dysfunction or even death. Large-scale genetic association studies have indicated that genetic variations affecting SARS-CoV-2 receptors (angiotensin-converting enzymes, transmembrane serine protease-2) and immune components (Interferons, Interleukins, Toll-like receptors and Human leukocyte antigen) are critical host determinants related to the severity of COVID-19. Genetic background, such as 3p21.31 and 9q34.2 loci were also identified to influence outcomes of COVID-19. In this review, we aimed to summarize the current literature focusing on human genetic factors that may contribute to the observed diversified severity of COVID-19. Enhanced understanding of host genetic factors and viral interactions of SARS-CoV-2 could provide scientific bases for personalized preventive measures and precision medicine strategies.
Keywords: COVID-19; SARS-CoV-2; critical illness; disease severity; genetic.
【저자키워드】 COVID-19, SARS-CoV-2, Critical illness, disease severity, genetic., 【초록키워드】 coronavirus, Interleukins, Respiratory failure, multi-organ dysfunction, Genetic, human leukocyte antigen, outcome, Toll-like receptor, SARS-CoV-2 receptor, Asymptomatic, severity of COVID-19, Genetic variation, death, morbidity and mortality, Enzymes, disease, Critical, mild infection, association, Interaction, preventive measure, determinant, acute respiratory syndrome, Factor, Precision, Serine, base, transmembrane, loci, Host, enhanced, caused, indicated, contribute, affecting, immune component, 【제목키워드】 Human, Genetic, Critical,