Abstract
Purpose: The primary purpose of this study is to identify if there is an underlying genetic predisposition for COVID-related macroglossia and if this susceptibility is higher among individuals of African heritage. Secondary objectives include determining if genetic testing of COVID-infected patients who are intubated and prone could identify patients with higher susceptibility to the development of macroglossia.
Methods: A retrospective chart review was completed for each patient, and prospectively, genetic and histopathologic analyses were completed. Whole-exome sequencing was completed on two patients; immunohistochemistry was completed on the COVID-positive tissue samples.
Results: Histopathology of the COVID-positive patient revealed significant peri-lymphocytic infiltrate, which was absent in the COVID-negative patient. Immunohistochemistry confirmed the presence of immune cells. Results from the whole-exome sequencing were inconclusive.
Conclusion: The findings of this study are consistent with others that have observed a lymphocytic infiltrate in the organs of patients infected with SARS-CoV-2. On histology, IHC highlighted a CD45 + predominance, indicating that a robust immune response is present in the tissues. The pathobiology of this phenomenon and its role in the development and/or persistence of massive macroglossia requires further study.
Keywords: COVID-19; Histopathology; Immunohistochemistry; Oral pathology; Oral surgery.
【저자키워드】 COVID-19, immunohistochemistry, Histopathology, oral pathology, Oral surgery., 【초록키워드】 immune response, susceptibility, Sequencing, Genetic, whole-exome sequencing, persistence, African, Genetic testing, Patient, immune cells, oral, histology, retrospective, Genetic predisposition, oral surgery, Intubated, tissues, individual, CD45, tissue samples, organ, Inconclusive, IHC, robust, Result, identify, include, analysis, infected with SARS-CoV-2, Secondary objective, 【제목키워드】 Patient, genomic, Side effect, massive, histologic,