Abstract
Despite the rising natural and vaccines mediated immunity, several countries have experienced a resurgence of the Coronavirus disease of 2019 (COVID-19) due to the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. From Alpha to Omicron, the variants of concern (VOC) have evolved several spike protein mutations that may have an impact on virus characteristics, such as transmissibility and antigenicity. In this review, we describe the evolution of SARS-CoV-2, summarize current knowledge of epidemiological and clinical features of the variants, and discuss the response strategies in terms of vaccines to reduce the burden of COVID-19.
Keywords: COVID-19; SARS-CoV-2; Spike mutations; Vaccines; Variant of concern.
【저자키워드】 COVID-19, SARS-CoV-2, Vaccines, spike mutations, Variant of concern., 【초록키워드】 Vaccine, coronavirus, Mutation, spike, VoC, knowledge, variants of concern, omicron, virus, variants, Spike protein, Characteristics, Transmissibility, Evolution of SARS-CoV-2, epidemiological, antigenicity, disease, clinical feature, acute respiratory syndrome, country, mediated immunity, reduce, rising, 【제목키워드】 Vaccine, SARS-CoV-2 variant, Spike protein,