Abstract
Background: The coronavirus disease (COVID-19) pandemic, which has been ongoing for more than 2 years, has become one of the largest public health issues. Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is one of the most important interventions to mitigate the COVID-19 pandemic. Our objective is to investigate the relationship between vaccination status and time to seroconversion.
Methods: We conducted a cross-sectional observational study during the SARS-CoV-2 B.1.617.2 outbreak in Jiangsu, China. Participants who infected with the B.1.617.2 variant were enrolled. Cognitive performance, quality of life, emotional state, chest computed tomography (CT) score and seroconversion time were evaluated for each participant. Statistical analyses were performed using one-way ANOVA, univariate and multivariate regression analyses, Pearson correlation, and mediation analysis.
Results: A total of 91 patients were included in the analysis, of whom 37.3, 25.3, and 37.3% were unvaccinated, partially vaccinated, and fully vaccinated, respectively. Quality of life was impaired in 30.7% of patients, especially for mental component summary (MCS) score. Vaccination status, subjective cognitive decline, and depression were risk factors for quality-of-life impairment. The chest CT score mediated the relationship of vaccination status with the MCS score, and the MCS score mediated the relationship of the chest CT score with time to seroconversion.
Conclusion: Full immunization course with an inactivated vaccine effectively lowered the chest CT score and improved quality of life in hospitalized patients. Vaccination status could influence time to seroconversion by affecting CT score and MCS score indirectly. Our study emphasizes the importance of continuous efforts in encouraging a full vaccination course.
Keywords: B.1.617.2 Delta variant; COVID-19; SARS-CoV-2; mental health; seroconversion time; vaccination.
【저자키워드】 COVID-19, SARS-CoV-2, mental health, vaccination., seroconversion time, B.1.617.2 Delta variant, 【초록키워드】 coronavirus disease, public health, coronavirus, vaccination, pandemic, Depression, cross-sectional, COVID-19 pandemic, variant, Infection, Delta, B.1.617.2, Intervention, hospitalized patients, risk factor, immunization, China, Chest computed tomography, Seroconversion, Chest CT, Inactivated vaccine, outbreak, Patient, Quality of life, Mediation analysis, Quality, patients, Analysis, Vaccination Status, emotional, cognitive, cognitive performance, Regression analyses, acute respiratory syndrome, effort, participant, ANOVA, impairment, Pearson correlation, Mental, mitigate, Jiangsu, Course, enrolled, performed, evaluated, conducted, analysis, affecting, was impaired, the SARS-CoV-2, 【제목키워드】 cross-sectional, Infection, Delta, B.1.617.2, Health, Seroconversion, Chest CT, COVID-19 vaccination, Patient,