Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible and virulent human-infecting coronavirus that emerged in late December 2019 in Wuhan, China, causing a respiratory disease called coronavirus disease 2019 (COVID-19), which has massively impacted global public health and caused widespread disruption to daily life. The crisis caused by COVID-19 has mobilized scientists and public health authorities across the world to rapidly improve our knowledge about this devastating disease, shedding light on its management and control, and spawned the development of new countermeasures. Here we provide an overview of the state of the art of knowledge gained in the last 2 years about the virus and COVID-19, including its origin and natural reservoir hosts, viral etiology, epidemiology, modes of transmission, clinical manifestations, pathophysiology, diagnosis, treatment, prevention, emerging variants, and vaccines, highlighting important differences from previously known highly pathogenic coronaviruses. We also discuss selected key discoveries from each topic and underline the gaps of knowledge for future investigations.
Keywords: SARS-CoV-2; clinical features; diagnosis; pathophysiology; prevention; reservoir hosts; transmission; treatment; vaccines; variants.
【저자키워드】 Treatment, SARS-CoV-2, Vaccines, Diagnosis, Transmission, prevention, Clinical features, pathophysiology, variants., reservoir hosts, 【초록키워드】 COVID-19, coronavirus disease, Coronaviruses, coronavirus, Epidemiology, knowledge, virus, variants, clinical manifestations, management, Respiratory disease, etiology, disease, acute respiratory syndrome, Topic, global public health, hosts, virulent, highly pathogenic, widespread, Wuhan, China, IMPROVE, selected, caused, highlighting, impacted, public health authority, 【제목키워드】 COVID-19, lesson, Year,