We investigated ChAdOx1 nCoV-19 (AZD1222) vaccine efficacy against SARS-CoV-2 variants of concern (VOCs) B.1.1.7 and B.1.351 in Syrian hamsters. We previously showed protection against SARS-CoV-2 disease and pneumonia in hamsters vaccinated with a single dose of ChAdOx1 nCoV-19. Here, we observe a 9.5-fold reduction of virus neutralizing antibody titer in vaccinated hamster sera against B.1.351 compared to B.1.1.7. Vaccinated hamsters challenged with B.1.1.7 or B.1.351 do not lose weight compared to control animals. In contrast to control animals, the lungs of vaccinated animals do not show any gross lesions. Minimal to no viral subgenomic RNA (sgRNA) and no infectious virus can be detected in lungs of vaccinated animals. Histopathological evaluation shows extensive pulmonary pathology caused by B.1.1.7 or B.1.351 replication in the control animals, but none in the vaccinated animals. These data demonstrate the effectiveness of the ChAdOx1 nCoV-19 vaccine against clinical disease caused by B.1.1.7 or B.1.351 VOCs. Emerging SARS-CoV-2 variants raise concerns about vaccine effectiveness. Here, the authors show that the ChAdOx1 nCoV-19 (AZD1222) vaccine protects Syrian hamsters from pulmonary infection and disease after infection with SARS-CoV-2 B.1.351 or B.1.1.7 variants.
【저자키워드】 Vaccines, Pathogens, Live attenuated vaccines, 【초록키워드】 Efficacy, Vaccine, Pneumonia, hamsters, B.1.351, SARS-CoV-2 variant, lung, virus, RNA, Replication, AZD1222, Viral, SARS-CoV-2 variants, B.1.1.7, animals, sera, Lungs, weight, VOCs, Antibody titer, Effectiveness, sgRNA, hamster, disease, ChAdOx1, ChAdOx1 nCoV-19, single dose, ChAdOx1 nCoV-19 vaccine, Neutralizing antibody titer, Pulmonary infection, Infectious virus, Pulmonary pathology, lose weight, reduction, SARS-CoV-2 disease, These data, lesions, clinical disease, B.1.1.7 variants, raise, observé, PROTECT, caused, investigated, infection with SARS-CoV-2, 【제목키워드】 SARS-CoV-2, hamster, PROTECT,