The outbreak of coronavirus disease 2019 (COVID-19) is a global health emergency. Various omics results have been reported for COVID-19, but the molecular hallmarks of COVID-19, especially in those patients without comorbidities, have not been fully investigated. Here we collect blood samples from 231 COVID-19 patients, prefiltered to exclude those with selected comorbidities, yet with symptoms ranging from asymptomatic to critically ill. Using integrative analysis of genomic, transcriptomic, proteomic, metabolomic and lipidomic profiles, we report a trans-omics landscape for COVID-19. Our analyses find neutrophils heterogeneity between asymptomatic and critically ill patients. Meanwhile, neutrophils over-activation, arginine depletion and tryptophan metabolites accumulation correlate with T cell dysfunction in critical patients. Our multi-omics data and characterization of peripheral blood from COVID-19 patients may thus help provide clues regarding pathophysiology of and potential therapeutic strategies for COVID-19. COVID-19 is a critical public health threat, but molecular characterizations of patients’ immunity is still lacking. Here the authors collected blood from patients with various disease severity, and prefiltered to exclude selected comorbidity, to obtain genomic, transcriptomic, proteomic, metabolomic and lipidomic profiles to report a trans-omics landscape.
【저자키워드】 viral infection, Antimicrobial responses, Systems analysis, Gene regulation in immune cells, 【초록키워드】 COVID-19, coronavirus disease, Neutrophils, Coronavirus disease 2019, Immunity, arginine, disease severity, neutrophil, Comorbidities, Comorbidity, Symptom, heterogeneity, Peripheral blood, T cell, Critically ill, Asymptomatic, pathophysiology, outbreak, Patient, Tryptophan, molecular, Integrative analysis, genomic, Critical, patients, metabolite, therapeutic strategy, critically ill patients, proteomic, COVID-19 patients, Blood, Analysis, COVID-19 patient, characterization, health emergency, Blood samples, profile, blood sample, help, profiles, critical patients, hallmark, public health threat, arginine depletion, T cell dysfunction, transcriptomic, metabolomic, selected, collected, reported, investigated, 【제목키워드】 COVID-19,