The COVID-19 outbreak is emerging as a significant public health challenge. Excessive production of proinflammatory cytokines, also known as cytokine storm, is a severe clinical syndrome known to develop as a complication of infectious or inflammatory diseases. Clinical evidence suggests that the occurrence of cytokine storm in severe acute respiratory syndrome secondary to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is closely associated with the rapid deterioration and high mortality of severe cases. In this review, we aim to summarize the mechanism of SARS-CoV-2 infection and the subsequent immunological events related to excessive cytokine production and inflammatory responses associated with ACE2-AngII signaling. An overview of the diagnosis and an update on current therapeutic regimens and vaccinations is also provided.
【저자키워드】 COVID-19, SARS-CoV-2, Cytokine storm, immune response, vaccination, therapy, Cytokines, Diagnosis, 【초록키워드】 severe acute respiratory syndrome coronavirus 2, public health, Inflammatory diseases, Cytokine storm, coronavirus, Cytokines, Inflammatory responses, SARS-COV-2 infection, Infection, cytokine, severe acute respiratory syndrome Coronavirus, Severe acute respiratory syndrome, Deterioration, COVID-19 outbreak, clinical, therapeutic, severe cases, Complication, respiratory, proinflammatory cytokines, mechanism, Signaling, Evidence, Inflammatory response, Vaccinations, regimen, secondary to, acute respiratory syndrome, acute respiratory syndrome coronavirus, syndrome, high mortality, clinical evidence, excessive cytokine production, immunological, event, Occurrence, develop, subsequent, provided, 【제목키워드】 viral infection, immune responses,